EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104
Identifieur interne : 000658 ( Main/Exploration ); précédent : 000657; suivant : 000659EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104
Auteurs : S. Boeck [Allemagne] ; A. Jung [Allemagne] ; R. P. Laubender [Allemagne] ; J. Neumann [Allemagne] ; R. Egg [Allemagne] ; C. Goritschan [Allemagne] ; U. Vehling-Kaiser [Allemagne] ; C. Winkelmann [Allemagne] ; L. Fischer Von Weikersthal [Allemagne] ; M. R. Clemens [Allemagne] ; T. C. Gauler [Allemagne] ; A. M Rten [Allemagne] ; S. Klein [Allemagne] ; G. Kojouharoff ; M. Barner ; M. Geissler ; T. F. Greten ; U. Mansmann [Allemagne] ; T. Kirchner [Allemagne] ; V. Heinemann [Allemagne]Source :
- British journal of cancer [ 0007-0920 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background: We aimed to identify molecular epidermal growth factor receptor (EGFR) tissue biomarkers in pancreatic cancer (PC) patients treated with the anti-EGFR agent erlotinib within the phase 3 randomised AIO-PK0104 study. Methods: AIO-PK0104 was a multicenter trial comparing gemcitabine/erlotinib followed by capecitabine with capecitabine/erlotinib followed by gemcitabine in advanced PC; primary study end point was the time-to-treatment failure after first- and second-line therapy (TTF2). Translational analyses were performed for KRAS exon 2 mutations, EGFR expression, PTEN expression, the EGFR intron 1 and exon 13 R497K polymorphism (PM). Biomarker data were correlated with TTF, overall survival (OS) and skin rash.
Affiliations:
- Allemagne
- Bade-Wurtemberg, Bavière, District de Haute-Bavière, District de Haute-Franconie, District de Karlsruhe
- Bayreuth, Heidelberg, Munich
- Université Louis-et-Maximilien de Munich
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Le document en format XML
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Boeck</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Jung, A" sort="Jung, A" uniqKey="Jung A" first="A." last="Jung">A. Jung</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Laubender, R P" sort="Laubender, R P" uniqKey="Laubender R" first="R. P." last="Laubender">R. P. Laubender</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Neumann, J" sort="Neumann, J" uniqKey="Neumann J" first="J." last="Neumann">J. Neumann</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Egg, R" sort="Egg, R" uniqKey="Egg R" first="R." last="Egg">R. Egg</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Goritschan, C" sort="Goritschan, C" uniqKey="Goritschan C" first="C." last="Goritschan">C. Goritschan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Vehling Kaiser, U" sort="Vehling Kaiser, U" uniqKey="Vehling Kaiser U" first="U." last="Vehling-Kaiser">U. Vehling-Kaiser</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Practice for Medical Oncology</s1><s2>Landshut</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Landshut</wicri:noRegion><wicri:noRegion>Practice for Medical Oncology</wicri:noRegion><wicri:noRegion>Practice for Medical Oncology</wicri:noRegion></affiliation></author><author><name sortKey="Winkelmann, C" sort="Winkelmann, C" uniqKey="Winkelmann C" first="C." last="Winkelmann">C. Winkelmann</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Internal Medicine, Krankenhaus Lutherstadt-Wittenberg</s1><s2>Lutherstadt-Wittenberg</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lutherstadt-Wittenberg</wicri:noRegion><wicri:noRegion>Krankenhaus Lutherstadt-Wittenberg</wicri:noRegion><wicri:noRegion>Lutherstadt-Wittenberg</wicri:noRegion></affiliation></author><author><name sortKey="Fischer Von Weikersthal, L" sort="Fischer Von Weikersthal, L" uniqKey="Fischer Von Weikersthal L" first="L." last="Fischer Von Weikersthal">L. Fischer Von Weikersthal</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Oncology, Gesundheitszentrum St Marien GmbH</s1><s2>Amberg</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Amberg</wicri:noRegion><wicri:noRegion>Gesundheitszentrum St Marien GmbH</wicri:noRegion><wicri:noRegion>Amberg</wicri:noRegion></affiliation></author><author><name sortKey="Clemens, M R" sort="Clemens, M R" uniqKey="Clemens M" first="M. R." last="Clemens">M. R. Clemens</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Internal Medicine I, Klinikum Mutterhaus Trier</s1><s2>Trier</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Klinikum Mutterhaus Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Gauler, T C" sort="Gauler, T C" uniqKey="Gauler T" first="T. C." last="Gauler">T. C. Gauler</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Medicine (Cancer Research), West German Cancer Center, University of Duisburg-Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University of Duisburg-Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="M Rten, A" sort="M Rten, A" uniqKey="M Rten A" first="A." last="M Rten">A. M Rten</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Surgery, University of Heidelberg</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Klein, S" sort="Klein, S" uniqKey="Klein S" first="S." last="Klein">S. Klein</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Internal Medicine IV, Klinikum Bayreuth</s1><s2>Bayreuth</s2><s3>DEU</s3><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Franconie</region><settlement type="city">Bayreuth</settlement></placeName></affiliation></author><author><name sortKey="Kojouharoff, G" sort="Kojouharoff, G" uniqKey="Kojouharoff G" first="G." last="Kojouharoff">G. Kojouharoff</name></author><author><name sortKey="Barner, M" sort="Barner, M" uniqKey="Barner M" first="M." last="Barner">M. Barner</name></author><author><name sortKey="Geissler, M" sort="Geissler, M" uniqKey="Geissler M" first="M." last="Geissler">M. Geissler</name></author><author><name sortKey="Greten, T F" sort="Greten, T F" uniqKey="Greten T" first="T. F." last="Greten">T. F. Greten</name></author><author><name sortKey="Mansmann, U" sort="Mansmann, U" uniqKey="Mansmann U" first="U." last="Mansmann">U. Mansmann</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Kirchner, T" sort="Kirchner, T" uniqKey="Kirchner T" first="T." last="Kirchner">T. Kirchner</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Heinemann, V" sort="Heinemann, V" uniqKey="Heinemann V" first="V." last="Heinemann">V. Heinemann</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0134801</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0134801 INIST</idno><idno type="RBID">Pascal:13-0134801</idno><idno type="wicri:Area/PascalFrancis/Corpus">000190</idno><idno type="wicri:Area/PascalFrancis/Curation">000A95</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000139</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000139</idno><idno type="wicri:doubleKey">0007-0920:2013:Boeck S:egfr:pathway:biomarkers</idno><idno type="wicri:Area/Main/Merge">000672</idno><idno type="wicri:Area/Main/Curation">000658</idno><idno type="wicri:Area/Main/Exploration">000658</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104</title><author><name sortKey="Boeck, S" sort="Boeck, S" uniqKey="Boeck S" first="S." last="Boeck">S. Boeck</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Jung, A" sort="Jung, A" uniqKey="Jung A" first="A." last="Jung">A. Jung</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Laubender, R P" sort="Laubender, R P" uniqKey="Laubender R" first="R. P." last="Laubender">R. P. Laubender</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Neumann, J" sort="Neumann, J" uniqKey="Neumann J" first="J." last="Neumann">J. Neumann</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Egg, R" sort="Egg, R" uniqKey="Egg R" first="R." last="Egg">R. Egg</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Goritschan, C" sort="Goritschan, C" uniqKey="Goritschan C" first="C." last="Goritschan">C. Goritschan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Vehling Kaiser, U" sort="Vehling Kaiser, U" uniqKey="Vehling Kaiser U" first="U." last="Vehling-Kaiser">U. Vehling-Kaiser</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Practice for Medical Oncology</s1><s2>Landshut</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Landshut</wicri:noRegion><wicri:noRegion>Practice for Medical Oncology</wicri:noRegion><wicri:noRegion>Practice for Medical Oncology</wicri:noRegion></affiliation></author><author><name sortKey="Winkelmann, C" sort="Winkelmann, C" uniqKey="Winkelmann C" first="C." last="Winkelmann">C. Winkelmann</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Internal Medicine, Krankenhaus Lutherstadt-Wittenberg</s1><s2>Lutherstadt-Wittenberg</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lutherstadt-Wittenberg</wicri:noRegion><wicri:noRegion>Krankenhaus Lutherstadt-Wittenberg</wicri:noRegion><wicri:noRegion>Lutherstadt-Wittenberg</wicri:noRegion></affiliation></author><author><name sortKey="Fischer Von Weikersthal, L" sort="Fischer Von Weikersthal, L" uniqKey="Fischer Von Weikersthal L" first="L." last="Fischer Von Weikersthal">L. Fischer Von Weikersthal</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Oncology, Gesundheitszentrum St Marien GmbH</s1><s2>Amberg</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Amberg</wicri:noRegion><wicri:noRegion>Gesundheitszentrum St Marien GmbH</wicri:noRegion><wicri:noRegion>Amberg</wicri:noRegion></affiliation></author><author><name sortKey="Clemens, M R" sort="Clemens, M R" uniqKey="Clemens M" first="M. R." last="Clemens">M. R. Clemens</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Internal Medicine I, Klinikum Mutterhaus Trier</s1><s2>Trier</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Klinikum Mutterhaus Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Gauler, T C" sort="Gauler, T C" uniqKey="Gauler T" first="T. C." last="Gauler">T. C. Gauler</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Medicine (Cancer Research), West German Cancer Center, University of Duisburg-Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>University of Duisburg-Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="M Rten, A" sort="M Rten, A" uniqKey="M Rten A" first="A." last="M Rten">A. M Rten</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Surgery, University of Heidelberg</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Klein, S" sort="Klein, S" uniqKey="Klein S" first="S." last="Klein">S. Klein</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Internal Medicine IV, Klinikum Bayreuth</s1><s2>Bayreuth</s2><s3>DEU</s3><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Franconie</region><settlement type="city">Bayreuth</settlement></placeName></affiliation></author><author><name sortKey="Kojouharoff, G" sort="Kojouharoff, G" uniqKey="Kojouharoff G" first="G." last="Kojouharoff">G. Kojouharoff</name></author><author><name sortKey="Barner, M" sort="Barner, M" uniqKey="Barner M" first="M." last="Barner">M. Barner</name></author><author><name sortKey="Geissler, M" sort="Geissler, M" uniqKey="Geissler M" first="M." last="Geissler">M. Geissler</name></author><author><name sortKey="Greten, T F" sort="Greten, T F" uniqKey="Greten T" first="T. F." last="Greten">T. F. Greten</name></author><author><name sortKey="Mansmann, U" sort="Mansmann, U" uniqKey="Mansmann U" first="U." last="Mansmann">U. Mansmann</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Kirchner, T" sort="Kirchner, T" uniqKey="Kirchner T" first="T." last="Kirchner">T. Kirchner</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, Ludwig-Maximilians-University of Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Heinemann, V" sort="Heinemann, V" uniqKey="Heinemann V" first="V." last="Heinemann">V. Heinemann</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15</s1><s2>Munich 81377</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><series><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. j. cancer</title><idno type="ISSN">0007-0920</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. j. cancer</title><idno type="ISSN">0007-0920</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advanced stage</term><term>Antineoplastic agent</term><term>Biological marker</term><term>Cancerology</term><term>Capecitabine</term><term>Clinical trial</term><term>Epidermal growth factor receptor</term><term>Erlotinib</term><term>Gemcitabine</term><term>Genetic translation</term><term>Human</term><term>Pancreas cancer</term><term>Phase III trial</term><term>Prodrug</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Erlotinib</term><term>Récepteur facteur croissance épiderme</term><term>Marqueur biologique</term><term>Cancer du pancréas</term><term>Traitement</term><term>Homme</term><term>Essai clinique phase III</term><term>Stade avancé</term><term>Traduction génétique</term><term>Capécitabine</term><term>Essai clinique</term><term>Cancérologie</term><term>Gemcitabine</term><term>Anticancéreux</term><term>Promédicament</term><term>Antipyrimidique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: We aimed to identify molecular epidermal growth factor receptor (EGFR) tissue biomarkers in pancreatic cancer (PC) patients treated with the anti-EGFR agent erlotinib within the phase 3 randomised AIO-PK0104 study. Methods: AIO-PK0104 was a multicenter trial comparing gemcitabine/erlotinib followed by capecitabine with capecitabine/erlotinib followed by gemcitabine in advanced PC; primary study end point was the time-to-treatment failure after first- and second-line therapy (TTF2). Translational analyses were performed for KRAS exon 2 mutations, EGFR expression, PTEN expression, the EGFR intron 1 and exon 13 R497K polymorphism (PM). Biomarker data were correlated with TTF, overall survival (OS) and skin rash.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Haute-Bavière</li><li>District de Haute-Franconie</li><li>District de Karlsruhe</li></region><settlement><li>Bayreuth</li><li>Heidelberg</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><noCountry><name sortKey="Barner, M" sort="Barner, M" uniqKey="Barner M" first="M." last="Barner">M. Barner</name><name sortKey="Geissler, M" sort="Geissler, M" uniqKey="Geissler M" first="M." last="Geissler">M. Geissler</name><name sortKey="Greten, T F" sort="Greten, T F" uniqKey="Greten T" first="T. F." last="Greten">T. F. Greten</name><name sortKey="Kojouharoff, G" sort="Kojouharoff, G" uniqKey="Kojouharoff G" first="G." last="Kojouharoff">G. Kojouharoff</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Boeck, S" sort="Boeck, S" uniqKey="Boeck S" first="S." last="Boeck">S. Boeck</name></region><name sortKey="Clemens, M R" sort="Clemens, M R" uniqKey="Clemens M" first="M. R." last="Clemens">M. R. Clemens</name><name sortKey="Egg, R" sort="Egg, R" uniqKey="Egg R" first="R." last="Egg">R. Egg</name><name sortKey="Egg, R" sort="Egg, R" uniqKey="Egg R" first="R." last="Egg">R. Egg</name><name sortKey="Fischer Von Weikersthal, L" sort="Fischer Von Weikersthal, L" uniqKey="Fischer Von Weikersthal L" first="L." last="Fischer Von Weikersthal">L. Fischer Von Weikersthal</name><name sortKey="Gauler, T C" sort="Gauler, T C" uniqKey="Gauler T" first="T. C." last="Gauler">T. C. Gauler</name><name sortKey="Goritschan, C" sort="Goritschan, C" uniqKey="Goritschan C" first="C." last="Goritschan">C. Goritschan</name><name sortKey="Goritschan, C" sort="Goritschan, C" uniqKey="Goritschan C" first="C." last="Goritschan">C. Goritschan</name><name sortKey="Heinemann, V" sort="Heinemann, V" uniqKey="Heinemann V" first="V." last="Heinemann">V. Heinemann</name><name sortKey="Jung, A" sort="Jung, A" uniqKey="Jung A" first="A." last="Jung">A. Jung</name><name sortKey="Kirchner, T" sort="Kirchner, T" uniqKey="Kirchner T" first="T." last="Kirchner">T. Kirchner</name><name sortKey="Klein, S" sort="Klein, S" uniqKey="Klein S" first="S." last="Klein">S. Klein</name><name sortKey="Laubender, R P" sort="Laubender, R P" uniqKey="Laubender R" first="R. P." last="Laubender">R. P. Laubender</name><name sortKey="M Rten, A" sort="M Rten, A" uniqKey="M Rten A" first="A." last="M Rten">A. M Rten</name><name sortKey="Mansmann, U" sort="Mansmann, U" uniqKey="Mansmann U" first="U." last="Mansmann">U. Mansmann</name><name sortKey="Neumann, J" sort="Neumann, J" uniqKey="Neumann J" first="J." last="Neumann">J. Neumann</name><name sortKey="Vehling Kaiser, U" sort="Vehling Kaiser, U" uniqKey="Vehling Kaiser U" first="U." last="Vehling-Kaiser">U. Vehling-Kaiser</name><name sortKey="Winkelmann, C" sort="Winkelmann, C" uniqKey="Winkelmann C" first="C." last="Winkelmann">C. Winkelmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104
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